Verapamil Is Usually Used To Treat Hypertension, But Is Helpful In Peyronie's Disease By Breaking Down A Protein Involved In Scarring.

These.nclude potassium para-aminobenzoate Potaba, 18 pentoxifylline acting through TGFβ1 inhibition, 19 and Co enzyme Q10 . 20 The efficacy of Interferon-alpha-2b in the early stages of the disease has been reported in recent publications but it was found to be less effective in cases where calcification of the plaque had occurred in common with many treatments. 21 22 23 Formulations of super oxide dismutase are also reported to be effective in Peyronie's disease. 24 Injections to plaques scar tissue formed by the inflammation with Verapamil may be effective in some patients, but a recent placebo controlled trial failed to show a significant improvement. valentine received his undergraduate degree from McDaniel College in Westminster, Maryland. Congenital curvature penis curvature from birth is exceedingly rare. The cause of this fibrous tissue is often not known. This man has Peyronie’s Disease as the cause of his crooked penis. In this picture, the indentation can be seen. Example of penis deformation from side. URL of this page: // Curvature of the penis is an abnormal bend in the penis that occurs during erection.

An X-ray will show calcium deposits when present. Sometimes a photograph of the erect penis is required to determine the degree of fibrosis. If surgical repair is being planned, there may be a need for more detailed testing of the penis to map out the best way to repair it. Treatment options were limited till of late, and were associated with a high risk of serious side-effects such as increased fibrosis and scarring, or impotence. It is important to realize that none of these are proven to be beneficial in all cases, and most are useful only in some men, in the acute phase. Initial treatment includes; injections of corticosteroids into the fibrous tissue to reduce inflammation oral treatment with drugs like pentoxifylline, colchicine, vitamins such as vitamin E shockwave lithotripsy to break up the hard plaque radiation other medications such as PABA, verapamil or tamoxifen Colchicine inhibits actively growing cells and is supposed to prevent fibroblast proliferation and fibrous tissue deposition. Verapamil is usually used to treat hypertension, but is helpful in Peyronie's disease by breaking down a protein involved in scarring. Recently an injectable form of the collagenase enzyme from the bacterium Clostridium histolyticum has been used successfully to treat this condition. This enzyme breaks up the fibrous collagen tissue of the scar. Alpha-interferon injections are also being used with some success. Surgery is the last resort, and is indicated in case of intractable pain during intercourse, when the degree of curvature makes intercourse impossible, or when the disease has entered the chronic phase despite the use of other treatment methods.

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The scar tissue is localized and responsible for the hallmark deformities of Peyronie's disease curvature and narrowing. At the enter for Reconstructive Urology, we offer treatment to straighten penis curvature. URL of this page: // Curvature of the penis is an abnormal bend in the penis that occurs during erection. The disease also may occur more frequently with men that develop: It occasionally can occur in younger men. In this picture, the indentation can be seen. Congenital curvature penis curvature from birth is exceedingly rare. Patients with this condition describe curvature of the penis during erection that has been present for as long as they can remember. Although upward penile curvature is common along with some curve to the side, some men also can develop a downward penile bend as shown in this picture of a one of our Peyronie’s Disease patients. It is usually first recognized around puberty or early adulthood. It affects men ages 40 to 60 and older.

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